There is a relatively new organization trying to take microfinancing to a new level, while also making microfinance a sustainable and profitable business model.
Here is their model as described on their website:
Our mission is to fight global poverty by increasing access to microfinance.Unitus envisions a world where microfinance is available to every individual. We work toward this vision by accelerating the growth of the world's highest-potential emerging microfinance institutions. We provide capital investments and capacity-building consulting, thus empowering these organizations to scale and provide life-changing financial services to dramatically more of the world's working poor.....
Unitus acts as a social venture capital investor for the microfinance industry. The organization identifies the highest-potential microfinance institutions (MFIs) in developing countries and helps accelerate their growth through capital investments and capacity-building consulting, thus empowering them to help dramatically more poor people worldwide.
In 2006 and 2007 Unitus received the Fast Company/Monitor Group Social Capitalist Award for their work in building microfinance in India and around the globe.
Entrepreneurship is not just a model for building wealth. It is a model that can, through free enterprise and business ownership, help transform the world in ways that models based on wealth redistribution and government dependency can never accomplish.
(Thanks to Ben Cunningham for recommending this post).

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